NAGLER LABORATORY
UNIVERSITY OF CHICAGO
DEPARTMENT OF PATHOLOGY
How do immune cells in the intestinal mucosa distinguish
innocuous dietary antigens and billions of commensal
bacteria from pathogenic microbes and mount an
appropriate response to each?
Our laboratory is pursuing several different,
but complimentary, lines of research aimed at examining the
mechanisms regulating non-responsiveness to
these stimuli in healthy individuals and its
abrogation in food allergy and inflammatory bowel
disease. Our murine disease models will provide
the pre-clinical basis for future translational studies
aimed ultimately at the development of novel
immunotherapeutic modalities.