NAGLER LABORATORY

UNIVERSITY OF CHICAGO

DEPARTMENT OF PATHOLOGY

How do immune cells in the intestinal mucosa distinguish

innocuous dietary antigens and billions of commensal

bacteria from pathogenic microbes and mount an

appropriate response to each?

Our laboratory is pursuing several different,

but complimentary, lines of research aimed at examining the

mechanisms regulating non-responsiveness to

these stimuli in healthy individuals and its

abrogation in food allergy and inflammatory bowel

disease. Our murine disease models will provide

the pre-clinical basis for future translational studies

aimed ultimately at the development of novel

immunotherapeutic modalities.